I think the most likely route to a reboot happen is NBCUniversal having some sort of development deal with a producer who is a huge fan of SLIDERS and pushes for NBCUniversal to take the property off the shelf. It's not terribly likely at all, but it happened with DOCTOR WHO. BBC had no desire to revive the series because they'd done it very cheaply in the past, saw no way to revive it inexpensively, knew science fiction in 2005 was pricey -- but they wanted to work with Russell T. Davies after the success of QUEER AS FOLK and THE SECOND COMING. And Davies didn't want to do anything but DOCTOR WHO. Once that starts, Quinn, Wade, Rembrandt and Arturo whether played by the originals or new actors, have a lot of obvious marketing avenues to become icons to a new generation of viewers.
I do think Slider_Quinn21 went way too far, way, way too far -- but the ideas themselves were pretty solid even if I objected to torturing and imprisoning the original cast. If you forced me to go with his next generation approach...
SLIDERS - SECOND GENERATION
Sarah Nyugen is a tech support worker who failed out of her physics program in grad school. Kai Geoffrey is a YouTube star who failed to hang on to his 15 minutes of fame after an ill-advised stunt at a suicide scene. John Galen is a politician who failed to retain office after a scandal involving a blimp, some helium tanks and a hot dog stand.
Geoffrey, in a desperate attempt to revive his career, attempts a video at the supposedly haunted Mallory house only to experience computer problems that send Sarah to his aid.
Sarah, fascinated by the remnants of Quinn's technology, accidentally triggers a vortex that ensnares her, Kai and John (who just happens to be driving by). They are sent to an Earth where Galen is the wealthiest man in America and he lives it up -- until it turns out identity theft is a capital crime and Galen is marked as an impostor. On the run, the three are aided in surviving this parallel Earth by a mysterious stranger who reveals himself to be Dr. Quinn Mallory.
Sarah triggering his tech drew his attention. Quinn slid to this Earth to investigate. But in helping these new sliders, Quinn accidentally damages his own system and now the four find themselves sliding randomly through the interdimension in a search for home with Quinn serving as an experienced slider who is hiding a secret of his own, a dark past from which he's running, a terrible reason for why he can never go home again...
I think it'd also be neat to have one episode of PHASE II in which Wade, Rembrandt and Arturo are called in to investigate the new sliders' disappearances and reassure us that our old friends are indeed alive and well and not... like, in jail or something. *casts a curious look at Slider_Quinn21*
But written all this, I think you'd be better off just starting over again with Quinn opening the vortex for the first time whether he's played by Jerry O'Connell or Lucas Till.